A CPC-shelterin-BTR axis regulates mitotic telomere deprotection

Abstract Telomeres prevent ATM activation Cappellini da festa by sequestering chromosome termini within telomere loops (t-loops).Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism.Using unbiased interactomics, biochemical screening, molecular biology, and super-re

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Assessing the Status of Yazd Province Medical Emergency and Accident Management Center in Terms of Necessary Standards for Air Emergencies

Background: Air emergency medical services provide advanced medical care to patients and critically injured as soon as possible to reduce injuries and casualties.In this study, the status of the Medical Emergency and Accident Management Center in Yazd Province in terms of the necessary standards for air emergencies was investigated and compared wit

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An Efficient Deep Learning Approach to Automatic Glaucoma Detection Using Optic Disc and Optic Cup Localization

Glaucoma is an eye disease initiated due to excessive intraocular pressure inside it and caused complete sightlessness at its progressed stage.Whereas timely glaucoma screening-based treatment can save the patient from complete vision loss.Accurate screening procedures are dependent on the availability of human experts who performs the manual analy

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